Recent studies have demonstrated that epidermal growth factor(EGF) and its receptor (EGFR) play an important role for the carcinogenesis and progression of various malignant tumors including breast cancer. In human breast cancer, EGFR status has
been
suggested as an independent prognostic factor, and has an inverse relationship between estrogen receptor(ER) by several investigators. Therefore EGFR expression may be important not only for the hormone-independent tumor growth, but also for
predicting poor prognosis.
In this study we investigated the correlation between EGFR status expressed by EGFR Cdna-mRNA in situ hybridization and size of tumor, nodal and ER status, and its relation to overall and disease-free survival rete in breast cancers among Korean.
@ES The results were as followed:
@EN 1) Thirty of 56(53.6%) cases showed reactivity in EGFR.
2) Lymph node status(P)=0.0026), ER(P=0.0078) and EGFR status(P=0.0421) were the powerful predictors of prognosis in breast cancers.
3) No significant correlation was found between the expression of EGFR and age, tumor size, nodal status, clinical stage and ER status.
4) There was inverse trend between the expression of EGFR and ER, but stastically not significant. ER netative-EGFR positive cancers had the worst 5 year survival rare(26.3±0.13 months) than those of other ER-EGFR status, and it is statisically
significant(P=0.0232).
These results suggested that EGFR status may be important for the prediction of prognosis, and the patients with ER negative-EGFR postoperative therapeutic modalities.
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